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Vardenafil Vs Sildenafil: Which One to Buy


Vardenafil Vs Sildenafil: Which One to Buy

When treating erectile dysfunction, doctors often recommend PDE-5 inhibitors (Phosphodiesterase 5 inhibitors). Common among these are Vardenafil and Sildenafil. So, when you are buying medication, you would want to know which would work best for you.

First of all, though, you should understand that these medications are in the same category and have both been proven to work on men who cannot get or sustain a hard erection. So deeper knowledge of these drugs can help determine which one you should buy. 



Vardenafil is a drug that is approved by the FDA for the treatment of ED. Unlike Sildenafil, it is a more recent introduction into the world of treating men’s sexual problems. The FDA approved it in 2003 and the first brand that used Vardenafil as its main ingredient was Levitra. However, nowadays you can find other brands of Vardenafil like Vilitra and Snovitra.



Sildenafil started as a test drug for the treatment of pulmonary hypertension. In the course of testing the drug, however, its ability to cause an erection in impotent patients was discovered.

Sildenafil was therefore the first erectile dysfunction medication approved by the FDA. It was approved in 1998 under the famous brand name Viagra. Other pharmaceutical companies have come up with generic Viagra brands that include Cenforce and Fildena.


How Vardenafil and Sildenafil work:

These two medications belong to the same category of drugs for the treatment of erectile dysfunction. The way they work is therefore the same, only that you may find that the effect of one may last longer than the other.

PDE5 inhibitors act on a hormone in the body called phosphodiesterase 5. This is also where they get their name from. They prevent this enzyme from acting and that allows an opposite enzyme called cGMP to increase in the body. cGMP causes relaxation of blood vessel muscles and that makes the vessels expand. More blood can flow through the vessels and reach the penis. A man’s penis requires accumulation of blood in the chamber in order to erect.

The medications may begin to work within 30 to 60 minutes from the time they are taken. However, when it comes to how long they can remain potent, Vardenafil may last longer than Sildenafil

Vardenafil can remain potent for anywhere between 5 and 8 hours. In some rare cases, it may even get up to 10 hours. But, what has been commonly noticed is that the drug reaches its peak after 5 hours and from then on the strength of the erection may diminish.

Sildenafil on the other hand is known to reach its peak after 4 hours. It is known to remain potent for as long as 6 hours but in rare cases longer. When Sildenafil reaches its peak performance, it will begin waning in strength after that.

Vardenafil vs Sildenafil: How fast do they work? 

Naturally, when determining which ED medication to buy, you may want to know which one will deliver results faster. However, both these medications have the same time for reaction. An erection can be attained within 30 minutes to one hour after you take either Sildenafil or Vardenafil.

Some patients may experience a delay in the action of the medication they take due to the foods they eat before swallowing the tablet. Fatty foods are known to slow down the ingestion of both Sildenafil and Vardenafil. Your general health can also be a factor in determining how fast the medication will work. You should also know that some generic brands of Vardenafil are administered under the tongue and this is believed to help quicken the time it takes for the medication to reach the bloodstream.

Pharmacists often encourage patients to minimize the amount of food they eat before taking the drugs. Alternatively, you can take them on an empty stomach for faster results.


Vardenafil Vs Sildenafil: Side effects

Another common comparison of medications is their side effects. You can opt for a drug that has fewer side effects than its alternative or one with the side effects lasting shorter than the other.

When it comes to Vardenafil and Sildenafil, they are both PDE5 inhibitors so the way they affect the body is similar. Therefore, the side effects are also the same. However, since Vardenafil lasts slightly longer than Sildenafil, you may experience the side effects longer when you take Vardenafil compared to Sildenafil.


The main side effects of these medicines are:

  • Headache nausea and dizziness are the most commonly reported side effects
  • A person on these drugs may also turn red in the face and neck (flushing)
  • These drugs can also cause a running stomach or indigestion
  • Some people also report back pain
  • On rare occasions, you may experience sleep problems
  • When taken overdose, a permanent erection can occur and will need emergency attention
  • Shortness of breath and fainting is another extreme side effect


Vardenafil Vs Sildenafil: Which one to buy

Both Vardenafil and Sildenafil are known to effectively act on the symptoms of erectile dysfunction. Over 90 percent of the patients with ED who took either of these drugs reported being able to get a firm erection which enabled them to have satisfactory sexual intercourse.

When buying the medications, you may keep in mind that Vardenafil may give you an extra hour of potency than Sildenafil. But this also means that it can give longer side effects.

What matters most though is that you take the medication as instructed by the doctor and you buy the brands that are sold by trusted pharmacies. Do not self-medicate since you will end up with more complications to deal with. At times, this may not be the right treatment for you either. Talk to a professional before you start treatment with any brand of Vardenafil or Sildenafil.


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